Genomic Insights into the Atopic Eczema-Associated Skin Commensal Yeast Malassezia sympodialis
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چکیده
منابع مشابه
Genomic Insights into the Atopic Eczema-Associated Skin Commensal Yeast Malassezia sympodialis
UNLABELLED Malassezia commensal yeasts are associated with a number of skin disorders, such as atopic eczema/dermatitis and dandruff, and they also can cause systemic infections. Here we describe the 7.67-Mbp genome of Malassezia sympodialis, a species associated with atopic eczema, and contrast its genome repertoire with that of Malassezia globosa, associated with dandruff, as well as those of...
متن کاملIdentification of small RNAs in extracellular vesicles from the commensal yeast Malassezia sympodialis
Malassezia is the dominant fungus in the human skin mycobiome and is associated with common skin disorders including atopic eczema (AE)/dermatitis. Recently, it was found that Malassezia sympodialis secretes nanosized exosome-like vesicles, designated MalaEx, that carry allergens and can induce inflammatory cytokine responses. Extracellular vesicles from different cell-types including fungi hav...
متن کاملNanovesicles from Malassezia sympodialis and Host Exosomes Induce Cytokine Responses – Novel Mechanisms for Host-Microbe Interactions in Atopic Eczema
BACKGROUND Intercellular communication can occur via the release of membrane vesicles. Exosomes are nanovesicles released from the endosomal compartment of cells. Depending on their cell of origin and their cargo they can exert different immunoregulatory functions. Recently, fungi were found to produce extracellular vesicles that can influence host-microbe interactions. The yeast Malassezia sym...
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Our understanding of the interactions between normal skin microbiota and the human host has been greatly extended by recent investigations. In their recent study in mBio, A. Gioti et al. (mBio 4[1]:e00572-12, 2013) sequenced the genome of the atopic eczema-associated yeast, Malassezia sympodialis, and compared its gene content and organization with that of Malassezia globosa, a species implicat...
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Atopic Eczema (AE) is a very common chronic skin inflammatory disease characterized by flares and remission phases [1]. AE is the most common form of inflammatory skin diseases affecting up to 20% of children [2]. It is a typical disease of paediatric age with 90% of cases appearing before 5 years of age. However it could persist in adult age in 30% of affected patients [3]. Recently Margolis e...
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ژورنال
عنوان ژورنال: mBio
سال: 2013
ISSN: 2161-2129,2150-7511
DOI: 10.1128/mbio.00572-12